文章摘要
芳香酰肼的合成新方法
Novel synthesis method of aromatic hydrazine
  
DOI:
中文关键词: 酰肼  1-芳甲酰基苯并三氮唑  苯并三氮唑  合成
英文关键词: acylhydrazine  1-arylformylbenzotriazole  benzotriazoles  synthesis
基金项目:湖南省科技计划项目(2013SK3161);理论化学与分子模拟省部共建教育部重点实验室开放课题(LKF0905)
作者单位
唐绪福1, 杨文前1, 腾珍珍1, 刘建2,谢文林1 1.湖南科技大学 化学化工学院,理论化学与分子模拟教育部重点实验室, 分子构效关系湖南省普通高校重点实验室, 湖南 湘潭 411201
2.深圳翰宇药业股份有限公司,广东 深圳 518057 
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中文摘要:
      报道了以苯并三氮唑合成芳香酰肼的新方法.以芳香酸和苯并三氮唑为原料,先合成1-芳甲酰基苯并三氮唑中间体,然后经水合肼肼解得到芳香酸酰肼.用乙腈-氯仿混合溶剂重结晶获得纯品,收率均在90%以上.产物结构经熔点、红外光谱和核磁共振谱确证.
英文摘要:
      Novel synthesis method of aromatic hydrazine by use of benzotriazole was reported. At first, the intermidates 1-arylformylbenzotriazoles were synthesized by reaction of benzotriazole and aromatic acid. And then, the aromatic hydrazines were prepared by hydrazinolysis of 1-arylformylbenzotriazoles with hydrazine hydrate, which was recrystallized with acetonitrile-trichloromethane, the yield of the product was more than 90%. The structure of the title compound was characterized by melting point, IR and1H NMR spectra.
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