文章摘要
氯乙酰芳胺类化合物的合成及表征
Synthesis and characterization of chloroacetyl aromatic amines
  
DOI:
中文关键词: 氯乙酰氯  取代苯胺  酰胺  合成
英文关键词: chloracetyl chloride  substituted aniline  amide  synthesis
基金项目:国家科技支撑计划项目子课题(2011BAE06B01);湖南省科学基金课题(11JJ3016)
作者单位
刘汉文,邹亚丽,唐子龙 湖南科技大学 化学化工学院, 理论化学与分子模拟省部共建教育部重点实验室, 湖南 湘潭 411201 
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中文摘要:
      以取代苯胺和氯乙酰氯为原料合成了一系列芳香酰胺类化合物,产率为80%~99%.对反应的后处理进行了简化,用热水洗涤反应混合物,不需要有机溶剂对反应混合物进行萃取,减少了有机溶剂的使用,更加符合绿色化学的要求.用IR, 1HNMR和13C NMR对产物的结构进行了分析与表征.
英文摘要:
      A series of aromatic amides were synthesized in yields of 80%~99%using substituted aniline and chloroacetyl chloride as materials. The structures of the products were characterized by IR, 1HNMR and 13C NMR. The post-treatment of the reactions were simplified only by washing the reaction mixtures with hot water, need not use organic solvent to extract the product from the mixture. The reduction use of organic solvent in post-treatment is in line with the requirements of the green chemistry.
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