文章摘要
精神分裂症起因的进化生物学分析
Evolutionary analysis of the cause of schizophrenia
  
DOI:
中文关键词: 精神分裂症  病因  进化
英文关键词: schizophrenia  cause  evolution
基金项目:
作者单位
孙祎喆 北京大学 医学部基础医学院北京 100083 
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中文摘要:
      精神分裂症受基因因素,自然环境因素以及心理应激因素等多种因素共同影响,但目前多数研究都只关注于其中一项,很少有假说能兼顾各种因素.针对精神分裂症研究的这种局限,从进化的角度,利用达尔文医学和进化心理学的方法对精神分裂症进行剖析,以推测其可能的进化史因,并解释环境因素与遗传因素等在精神分裂症发生发展中的作用.同时,对影响精神分裂症发病率的多种环境因素进行了分析,并讨论了精神分裂症的性别特异性、年龄特异性等发病特性,在此基础上提出和论证了一个新的精神分裂症病因的理论假说:“精神分裂症相关基因是一组用于应对不利生存环境的基因,受环境因素的反馈控制.当环境过于恶劣时,这些基因的过度表达就会引发精神分裂症.”
英文摘要:
      The schizophrenia is affected by the genetic factors, natural environmental factors, psychological stress factors and many other factors. However, most studies only focus on one of them, and few hypothesis can give attention to multi-factors. Therefore, the viewpoint of Darwinian medicine and evolutionary psychology was adopted to analyze the schizophrenia in order to speculate the cause of schizophrenia, and explain how the genetic factors and the natural environmental factors affect the schizophrenia. On this basis, the characteristics of the onset of the schizophrenia was analyzed, and a new theory on the cause of the schizophrenia was putting forward and demonstrating: the related genes of schizophrenia was a group of genes replying for the adverse environment, under the feedback control of the environmental factors. When the environment was bad, the over expression of the genes cause the schizophrenia.
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