| 本文已被：浏览 3036次 下载 315次 |
码上扫一扫！ |
|
|
| 芳香酰肼的合成新方法 |
|
唐绪福1, 杨文前1, 腾珍珍1, 刘建2,谢文林11,2
|
|
1.湖南科技大学 化学化工学院,理论化学与分子模拟教育部重点实验室, 分子构效关系湖南省普通高校重点实验室, 湖南 湘潭 411201;2.深圳翰宇药业股份有限公司,广东 深圳 518057
|
|
| 摘要: |
| 报道了以苯并三氮唑合成芳香酰肼的新方法.以芳香酸和苯并三氮唑为原料,先合成1-芳甲酰基苯并三氮唑中间体,然后经水合肼肼解得到芳香酸酰肼.用乙腈-氯仿混合溶剂重结晶获得纯品,收率均在90%以上.产物结构经熔点、红外光谱和核磁共振谱确证. |
| 关键词: 酰肼 1-芳甲酰基苯并三氮唑 苯并三氮唑 合成 |
| DOI： |
| 分类号:O625.5 |
| 基金项目:湖南省科技计划项目(2013SK3161);理论化学与分子模拟省部共建教育部重点实验室开放课题(LKF0905) |
|
| Novel synthesis method of aromatic hydrazine |
|
TANG Xu-fu1, YANG Wen-qian1, TENG Zhen-zhen1, LIU Jian2, XIE Wen-lin11,2
|
|
1.Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education, Hunan Provincial University Key Laboratory of QSAR/QSPR , School of Chemistry and Chemical Engineering,Hunan University of Science and Technology, Xiangtan 411201, China;2. Shenzhen Hanyu Pharmaceutical Co., Ltd., Shenzhen 518057, China
|
| Abstract: |
| Novel synthesis method of aromatic hydrazine by use of benzotriazole was reported. At first, the intermidates 1-arylformylbenzotriazoles were synthesized by reaction of benzotriazole and aromatic acid. And then, the aromatic hydrazines were prepared by hydrazinolysis of 1-arylformylbenzotriazoles with hydrazine hydrate, which was recrystallized with acetonitrile-trichloromethane, the yield of the product was more than 90%. The structure of the title compound was characterized by melting point, IR and1H NMR spectra. |
| Key words: acylhydrazine 1-arylformylbenzotriazole benzotriazoles synthesis |
