| 摘要: |
| 以取代苯胺和氯乙酰氯为原料合成了一系列芳香酰胺类化合物,产率为80%~99%.对反应的后处理进行了简化,用热水洗涤反应混合物,不需要有机溶剂对反应混合物进行萃取,减少了有机溶剂的使用,更加符合绿色化学的要求.用IR, 1HNMR和13C NMR对产物的结构进行了分析与表征. |
| 关键词: 氯乙酰氯 取代苯胺 酰胺 合成 |
| DOI： |
| 分类号:O621.3 |
| 基金项目:国家科技支撑计划项目子课题(2011BAE06B01);湖南省科学基金课题(11JJ3016) |
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| Synthesis and characterization of chloroacetyl aromatic amines |
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LIU Han-wen, ZOU Ya-li, TANG Zi-long
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Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education of China,School of Chemistry and Chemical Engineering,Hunan University of Science and Technology,Xiangtan 411201,China
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| Abstract: |
| A series of aromatic amides were synthesized in yields of 80%~99%using substituted aniline and chloroacetyl chloride as materials. The structures of the products were characterized by IR, 1HNMR and 13C NMR. The post-treatment of the reactions were simplified only by washing the reaction mixtures with hot water, need not use organic solvent to extract the product from the mixture. The reduction use of organic solvent in post-treatment is in line with the requirements of the green chemistry. |
| Key words: chloracetyl chloride substituted aniline amide synthesis |
