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| 5-取代-4-羟基苯甲氨基-3-巯基-1,2,4-三唑的无溶剂合成 |
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白珊1,李尚儒2,何晶晶2,张金改2,张慧霖2,骆春香2,谢文林2,31,2,3
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1.长沙环境保护职业技术学院，湖南 长沙 410004;2. 湖南科技大学 化学化工学院，湖南 湘潭411201;3. 湖南科技大学 理论有机化学与功能分子教育部重点实验室，湖南 湘潭 411201
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| 摘要: |
| 在无溶剂条件下，由羟基苯甲醛,5-取代-3-巯基-4-氨基-1,2,4-三唑,对甲苯磺酸经过室温研磨合成了5-取代-4-羟基苯亚甲氨基-3-巯基-1,2,4-三唑，此化合物再经硼氢化钠还原得到5-取代-4-羟基苯甲氨基-3-巯基-1,2,4-三唑衍生物.其结构分别用IR，NMR 和MS 进行了表征.此方法具有反应条件温和，操作简单，产率高等优点，是一种有效合成5-取代-4-羟基苯甲氨基-3-巯基-1,2,4-三唑衍生物的新方法. |
| 关键词: 1,2,4-三唑 羟基苯甲醛 席夫碱 无溶剂 合成 |
| DOI： |
| 分类号:626 |
| 基金项目:国家自然科学基金资助项目（21571058）；湖南省自然科学基金资助项目（2015JJ4026） |
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| Synthesis of 5-substituted-3-hydrosulfuryl-4-hydroxybenzylamino-1,2,4-triazole under solvent-free conditions |
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Bai Shan1, Li Shangru2, He Jingjing2, Zhang Jingai2, Zhang Huilin2, Luo Chunxiang2, Xie Wenlin2,31,2,3
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1. Changsha Enviromental Protection College, Changsha 410004， China;2. School of Chemistry and Chemical Engineering， Hunan University of Science and Technology，Xiangtan 411201， China;3. Key Laboratory of Theoretical Organic Chemistry and Function Molecules Ministry of Education，
Hunan University of Science and Technology，Xiangtan 411201， China
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| Abstract: |
| 5-substituted-3-hydrosulfuryl-4-hydroxybenzmethyleneamino-1,2,4-triazole were synthesized by reaction of 5-substituted-3-hydrosulfuryl-4-amino-1,2,4-triazole and hydroxybenzaldehyde in the presence of p-toluenesulfonic acid under solvent-free conditions by grinding at room temperature, and then, the synthesized compounds were reduced to 5-substituted-3-hydrosulfuryl-4-hydroxybenzylamino-1,2,4-triazole , The structures of the products were characterized by IR，NMR and MS. The procedure offers several advantages including milder reaction conditions，easier work-up and higher yields, It is a novel synthesis method of 5-substituted-3-hydrosulfuryl-4-arylmethylamino-1,2,4-triazole. |
| Key words: 1,2,4-triazole hydroxybenzaldehyde schiff base solvent-free synthesis |
