The influence of wall with openings of interfering building and distance on roof pressure and vulnerable areas pressure for two tandem gable roof low-rise buildings were investigated by computational fluid dynamics software Fluent which RNG k-ε model was added in. The results show that internal pressure of interfering building is clearly affected by openings on windward wall and leeward wall and distance changing, when the distance is 12 m and the opening area on windward wall is twice as big as it on leeward wall, the mean internal wind pressure coefficient was up to 1.41. The combined action of internal pressure and external pressure at operation conditions of wall with openings made the roof have a stronger negative pressure than building with no openings, area of leeward ridge have a biggest negative pressure in all areas, maximum of the value is -2.34, the mean value is -1.9 which increased by 90% comparing with non-opening operation condition. Interfered building is also obviously influenced by the appearing of openings. The study of building with openings in group can help us to understand damage mechanism of group buildings and have practical significance for wind resistance research on low buildings of coastal areas.