According to the ecological footprint theory and method , the calculation of the ecological footprint was lauched about 18 City of Henan Province in 2010. The result indicates that the regional development in Henan Province is in an unsustainable position . Among them, Pingdingshan and Jiyuan are in a state of strong unsustainable development,and their ecological deficit reach to 2.510 2 hm2 and 2.093 0 hm2; The cities of Zhengzhou, Luoyang, Jiaozuo, Sanmenxia, Anyang, Hebi are in a state of unsustainable development; The other 10 cities are in the state of weak unsustainable development. At the same time, by calculating the ecological footprint of GDP, Zhengzhou and Luohe have the higher efficiency of resource utilization, and the lower efficiency of resource use are Pingdingshan. In response to these circumstances, some strategies are put forward to improve the sustainable development of regional strategies.