Recently years,many water hazards caused by burst of water cells formed by overburden stratum separation, water hazards is often difficult to predict, so need study it three kinds of patterns were provided, they were hydrodynamic water inrush, hydrostatic water inrush, and repetitive disturbance water inrush, respectively, aimed at hydrodynamic water inrush, the separation of the broken distance was studied, the calculation formula was derrived. By the simulation and the measured data, the development regularity of strata separation and broken distance were studied on, and it pointed out that water hazards caused by burst of water cells formed by overburden stratum separation prevention, focus on the development in the correct position was expected to separation, separation and development based on the expected location, advanced drilling construction guidance, to prevent water hazards caused by burst of water cells formed by overburden stratum separation.