The high-speed camshaft grinder spindle system was taken as the research object, the three-dimensional finite element model(FEM) of spindle system was established.In the FEM model,the bearing was simplified to the elastic part to support the spindle system. The static analysis ,the modal analysis and the harmonic response analysis of the spindle system were done by FEM software Ansys Workbench.Stress and strain distributing cloud graphs,the first six frequencies response ,mode shape and frequency response curve were obtained.The static stiffness and corresponding critical speed also were calculated out.The result proves that the spindle system do not occur resonance in its working process,and the resonance frequency range of the spindle is near 2 800 Hz. Verifying test results of the static stiffness agree with finite element analysis in the range of the error 12.9%.