In order to comprehensively study the dynamic properties of steel-concrete composite frame structures, the parameter analysis on dynamic performances of single layer and single span composite frame, which consists of steel pipe concrete columns and composite beams, was conducted. The influences of steel ratio, slenderness ratio, linear stiffness ratio, axial compression ratio and shear connection degree on natural frequency and seismic responses of steel -concrete composite frame were discussed. The results show that the natural frequency increases with the increase of steel ratio and linear stiffness ratio. However, natural frequency decreases with the increase of column slenderness ratio. The shear connection degree of composite beams exerts unclear effect on the natural frequency. Seismic response decreases with the increase of column’s steel ratio, but increases with the increase of the slenderness ratio and the decrease of the linear stiffness ratio. And axial compression ratio has little influence on the peak value of composite frame’s seismic response. When the degree of shear connection is greater than 0.73, it has no obvious effect on seismic response. According to parameter analysis results, the influence laws of all parameters are obtained. Thus, the rational design scopes of all parameters are provided in order to give a reference for practical engineering.