The experiment was illustrated on comprehensive recycling to certain tailings. Based upon conditioning tests on grinding system and floatation reagent, the open circuit test was conducted, from which 623% of Zinc grade was obtained with a recycling rate of 61.56% of Zinc crude concentrate and 6.00% of cassiterite grade was gotten with a recycling rate of 40.00% of cassiterite crude concentrate. Specifically, the contents of Zinc, Cassiterite, Fe and Arsenic in the very tailings were 0.10%, 0.07%, 3.92% and 0.17% respectively. A research on floatation mechanism of Cassiterite’s monomineral was also experimented which discoverd the collecting capacity of BHA to the next 3 minerals was put in order with Cassiterite>Calcite>Quartz. Besides, the best pH for floatation of Cassiterite was 9 and Cu2+ was able to restrain cassiterite that was very easy to be activated by Pb2+.